(4-Bromobutoxy)benzene → 1-(2-Phenoxyethyl)piperazine

HRID 638535

反応式

HRID 638535 の反応式
[O:1]([CH2:8][CH2:9]CCBr)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)=O>CC(O)C>[O:1]([CH2:8][CH2:9][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 70986(4-Bromobutoxy)benzeneHCID 821911-Piperazinecarboxaldehyde

生成物 1

HCID 2331871-(2-Phenoxyethyl)piperazine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

The procedure of Example 2 was repeated in entirety substituting 57.0 g (0.27 moles) of 2-bromoethyl phenyl ether for 4-phenoxybutyl bromide, using 61.6 g (0.54 moles) of 1-formylpiperazine in 300 ml of 2-propanol and refluxing the mixture for 8 hours. Evaporation of the final dried chloroform extracts gave 35 g of 1-[2-phenoxyethyl]piperazine as an oil.

後処理

  1. temperaturerefluxing the mixture for 8 hours
  2. customEvaporation of the final dried chloroform extracts

出典と根拠

ORDレコード
ord-dad50e4304ca4efda3bc70ede21fbfed
出典データセット
uspto-grants-1985_12
特許番号
US04562189

関連ノート

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