Hydrochloric Acid → HCID 66811347、化合物

HRID 638712

反応式

HRID 638712 の反応式
C[O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1.[ClH:21]>>[ClH:21].[NH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[CH:15][CH:14]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 497644916-(4-Acetylaminophenoxy)-hexanoic acid methyl ester

生成物 1

HCID 66811347HCID 66811347、化合物収率 55.6%

反応条件

温度
10 °C

実験手順

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

後処理

  1. temperaturewas refluxed for 48 hours
  2. distillationExcess concentrated hydrochloric acid was distilled off in vacuum
  3. filtrationfiltered hot
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-aaaf3cd83c2b4643bc5b4bb389e8ae5a
出典データセット
uspto-grants-2010_04
特許番号
US07691364B2

関連ノート

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