Aluminium lithium hydride → HCID 68712490、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[CH2:5][N:6]1[CH2:9][CH:8]([C:10]#[N:11])[CH2:7]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[CH2:5][N:6]1[CH2:9][CH:8]([CH2:10][NH2:11])[CH2:7]1参加物
4
実験手順
A solution of 1-(3,4-Dichloro-benzyl)-azetidine-3-carbonitrile (0.083 g, 0.347 mmol) in dry THF (2 ml) cooled to 0° C. is treated with a 1.0 M solution of lithium aluminium hydride in THF (0.347 ml). The reaction mixture is allowed to warm to ambient temperature and stirred for a one hour. The reaction mixture is quenched with saturated sodium sulphate solution and filtered. The filtrate is evaporated to afford the title compound. [MH] 244.97.
後処理
- customThe reaction mixture is quenched with saturated sodium sulphate solution
- filtrationfiltered
- customThe filtrate is evaporated
出典と根拠
- ORDレコード
- ord-c8f863142151472fb2475069e962fa41
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691841B2
反応ノート
読み込み中…