(Imidazo[2,1-b]benzothiazol-2-yl)methanol → Imidazo[2,1-b][1,3]benzothiazole-2-carbaldehyde
反応式
[N:1]1[C:2]([CH2:13][OH:14])=[CH:3][N:4]2[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[S:6][C:5]=12>C(Cl)Cl.O=[Mn]=O>[CH:13]([C:2]1[N:1]=[C:5]2[N:4]([CH:3]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[S:6]2)=[O:14]参加物
4
実験手順
To a stirred solution of imidazo[2,1-b]-benzthiazole-2-methanol (2.04 g, 10 mmol) in methylene chloride (200 ml), activated MnO2 (15 g, excess) was added. The reaction mixture was stirred at room temperature for 24 h and filtered through a pad of celite. The reaction mixture was concentrated and the product was purified by silica gel column chromatography by eluting it with 75% ethyl acetate; hexane. Brown solid; Yield: 800 mg, 40%; M+H 203.
後処理
- filtrationfiltered through a pad of celite
- concentrationThe reaction mixture was concentrated
- customthe product was purified by silica gel column chromatography
- washby eluting it with 75% ethyl acetate
出典と根拠
- ORDレコード
- ord-321b54278d944c3d92deb974ab67bf9f
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691842B2
反応ノート
読み込み中…