Trifluoroacetic acid → 4-Bromo-6-methoxyquinolin-3-amine

HRID 639003ノート

反応式

HRID 639003 の反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[Br:18])=[CH:15][C:14]([O:19][CH3:20])=[CH:13][CH:12]=2)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[Br:18])=[CH:15][C:14]([O:19][CH3:20])=[CH:13][CH:12]=2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68455075(4-Bromo-6-methoxy-quinolin-3-yl)-carbamic acid tert-butyl ester

生成物 1

HCID 684539074-Bromo-6-methoxyquinolin-3-amine収率 101.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(4-Bromo-6-methoxy-quinolin-3-yl)-carbamic acid tert-butyl ester (22.7 g, 0.0643 mole) was dissolved in CH2Cl2 (200 mL) and treated with trifluoroacetic acid (100 mL). After 3.5 hr at RT, the mixture was concentrated and the residue was dissolved in water. The solution was made basic with aqueous sodium carbonate. The precipitate was filtered off, washed with water, and dried at 40° C. in vacuo overnight, to give the title compound (16.46 g, 101%) as a white solid: MS (ES) m/e 254/256 (M+H)+.

後処理

  1. concentrationthe mixture was concentrated
  2. dissolutionthe residue was dissolved in water
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried at 40° C. in vacuo overnight

出典と根拠

ORDレコード
ord-f62c60dc319b42548a579005e7f442ea
出典データセット
uspto-grants-2010_04
特許番号
US07691850B2

反応ノート

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