Bromine → methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

HRID 639313ノート

反応式

HRID 639313 の反応式
[OH:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[N:6][CH:7]=1.[Br:12]Br>C(Cl)(Cl)Cl>[CH3:11][O:10][C:8]([C:5]1[CH:4]=[N:3][C:2]([OH:1])=[C:7]([Br:12])[N:6]=1)=[O:9]

参加物

4

反応物 2

HCID 24408BromineHCID 178498852HCID 178498852、化合物

生成物 1

HCID 178498844methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 2 g (13 mmol) methyl 5-hydroxypyrazine-2-carboxylate (commercially available), 0.192 g (0.65 mmol) FeBr3, 0.7 mL (14 mmol) Br2 in 20 mL CHCl3 was refluxed for 16 h. After evaporation of all volatiles the residue was used without further purification in the consecutive step.

後処理

  1. temperaturewas refluxed for 16 h
  2. customAfter evaporation of all volatiles the residue
  3. customwas used without further purification in the consecutive step

出典と根拠

ORDレコード
ord-d267403c5fb9427d90223a22bfd46cf5
出典データセット
uspto-grants-2010_04
特許番号
US07691863B2

反応ノート

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