Methyl 2-amino-2-ethylbutanoate → 2-Ethyl-2-[(6-isopropoxy-5-piperidin-1-yl-pyrazine-2-carbonyl)-amino]-butyric acid methyl ester

反応式

OC[C@@H](NC(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)CC(C)C.[CH:26]([O:29][C:30]1[N:35]=[C:34]([C:36]([OH:38])=O)[CH:33]=[N:32][C:31]=1[N:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1)([CH3:28])[CH3:27].[CH3:45][O:46][C:47](=[O:54])[C:48]([NH2:53])([CH2:51][CH3:52])[CH2:49][CH3:50]>>[CH3:45][O:46][C:47](=[O:54])[C:48]([CH2:51][CH3:52])([NH:53][C:36]([C:34]1[CH:33]=[N:32][C:31]([N:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[C:30]([O:29][CH:26]([CH3:27])[CH3:28])[N:35]=1)=[O:38])[CH2:49][CH3:50]

参加物

反応物 3

HCID 13412527Methyl 2-amino-2-ethylbutanoate

HCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

HCID 685694516-Isopropoxy-5-piperidin-1-yl-pyrazine-2-carboxylic acid

生成物 1

HCID 248315772-Ethyl-2-[(6-isopropoxy-5-piperidin-1-yl-pyrazine-2-carbonyl)-amino]-butyric acid methyl ester

実験手順

In analogy to the procedure described for the synthesis of 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-Isopropoxy-5-piperidin-1-yl-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 393.3 (M+H).