N-phenyl-2-naphthylamine → n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

HRID 639359ノート

反応式

HRID 639359 の反応式
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17](S(C)(=O)=O)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4].[CH:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][C:27]=1[NH:36]C1C=CC=CC=1>C(#N)C>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17]([NH:36][C:27]2[CH:28]=[CH:29][C:30]4[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH:26]=2)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4]

参加物

4

反応物 2

HCID 8679N-phenyl-2-naphthylamineHCID 59254867N-methyl-4-(2-(methylsulfonyl)quinazolin-6-yloxy)picolinamide

生成物 1

HCID 59254846n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
82.5 °C

実験手順

N-methyl[4-(2-methylsulfonylquinazolin-6-yloxy)(2-pyridyl)]carboxamide 15 (1 eq) was treated with 2-naphthylaniline (2 eq) in acetonitrile (1 M) and heated at 80-85° C. The mixture was evaporated and purified on preparative chromatography to give the product.

後処理

  1. customThe mixture was evaporated
  2. custompurified on preparative chromatography
  3. customto give the product

出典と根拠

ORDレコード
ord-283a518dea0649db9cded85a181d7430
出典データセット
uspto-grants-2010_04
特許番号
US07691866B2

反応ノート

読み込み中…