1-(2-Chloroethoxy)-4-nitrobenzene → 4-(2-Chloroethoxy)aniline

HRID 639372ノート

反応式

HRID 639372 の反応式
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1>C(O)C.O=[Pt]=O.C(Cl)Cl>[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1

参加物

5

反応物 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

生成物 1

HCID 1196994-(2-Chloroethoxy)aniline

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

36 g (0.178 Mol) of 1-(2-Chloro-ethoxy)-4-nitro-benzene is dissolved in 360 mL of ethanol and subjected to catalytic hydration at rt using PtO2 (1.5 g) as catalyst. The resulting suspension is diluted with CH2Cl2, filtered, and concentrated to approx. 150 mL. After cooling to 0° C. the crystals are filtered off, washed and dried at 60° C. under vacuum to obtain 4-(2-chloro-ethoxy)-phenylamine. Title compound: m.p.: 87-91° C.; ES-MS: 172 [M+H]+; single peak at tR=2.73 min (System 1).

後処理

  1. customsubjected to catalytic hydration at rt
  2. filtrationfiltered
  3. concentrationconcentrated to approx. 150 mL
  4. filtrationare filtered off
  5. washwashed
  6. customdried at 60° C. under vacuum

出典と根拠

ORDレコード
ord-49fe89710516443cb85d5cc9e60bff6f
出典データセット
uspto-grants-2010_04
特許番号
US07691855B2

反応ノート

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