4-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine → 2-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

HRID 639442ノート

反応式

HRID 639442 の反応式
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](CC2C=CC=CC=2)[CH2:9][CH2:8]1>[OH-].[Pd+2].[OH-].CO>[O:20]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

参加物

4

反応物 1

HCID 462231014-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine

生成物 1

HCID 532560872-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

20% Palladium hydroxide (100 mg) was added to the methanol solution (5 mL) containing 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-benzylpiperidine (252 mg) at 0° C., followed by stirring at room temperature for 5 hrs. under a hydrogen atmosphere. The reaction mixture was filtered to remove the palladium catalyst, followed by concentration under reduced pressure to give the title compound.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customto remove the palladium catalyst
  3. concentrationfollowed by concentration under reduced pressure

出典と根拠

ORDレコード
ord-8989cc46dee44dd7a73021652d3582be
出典データセット
uspto-grants-2010_04
特許番号
US07691860B2

反応ノート

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