Hydrochloric Acid → 1H-pyrrolo(2,3-c)pyridine-7-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][CH:8]=[C:9]2[CH:13]=[CH:12][NH:11][C:10]=12)=[O:4].[OH-].[K+].Cl>C1COCC1>[NH:11]1[C:10]2=[C:5]([C:3]([OH:4])=[O:2])[N:6]=[CH:7][CH:8]=[C:9]2[CH:13]=[CH:12]1参加物
5
実験手順
1H-Pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester (example E1, 50 mg, 0.28 mmol) was dissolved in THF (0.57 mL) and treated with 2 M aq. potassium hydroxide solution (0.57 mL, 1.1 mmol), then after 1 h acidified with 2M aq. hydrochloric acid solution and extracted with dichloromethane. The aqueous layer was evaporated and the residue was taken up in methanol and the residue was taken up in methanol and filtered. The filtrate was evaporated to afford the title compound (71 mg), which contained an unspecified amount of potassium chloride. MS (EI) 118.1 (100), 162.1 (53, M+); 1H-NMR (300 MHz, CD3OD): 8.30-8.25 (m, 2H), 8.24 (d, J=3.0, 1H), 7.07 (d, J=3.0, 1H).