Hydrochloric Acid → 3-(2-Cyanoethyl)benzaldehyde

HRID 639725ノート

反応式

HRID 639725 の反応式
[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]2OCC[O:12]2)[CH:8]=[CH:9][CH:10]=1)#[N:2].Cl>O1CCCC1>[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[CH:11]=[O:12])#[N:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 231317192-[3-(2-Cyanoethyl)phenyl]-[1,3]dioxolane

生成物 1

HCID 114992593-(2-Cyanoethyl)benzaldehyde収率 97.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 3.52 g of 2-[3-(2-cyanoethyl)phenyl]-[1,3]dioxolane was added 60 ml of tetrahydrofuran to dissolve this, and 20 ml of 6 N hydrochloric acid was added. After stirred at room temperature overnight and then concentrated under reduced pressure, ethyl acetate was added, and this was washed successively with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution. After dried over anhydrous magnesium sulfate, concentration under reduced pressure afforded 2.68 g of 3-(2-cyanoethyl)benzaldehyde [Compound No. (m)].

後処理

  1. additionwas added
  2. concentrationconcentrated under reduced pressure, ethyl acetate
  3. additionwas added
  4. washthis was washed successively with an aqueous potassium carbonate solution
  5. dry with materialAfter dried over anhydrous magnesium sulfate, concentration under reduced pressure

出典と根拠

ORDレコード
ord-07b0160f8e4f4724b053b3703e867617
出典データセット
uspto-grants-2010_04
特許番号
US07691883B2

反応ノート

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