Sodium hydride → 4-(4-Cyclopropyl-5-{1-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4H-[1,2,4]triazol-3-yl)-pyridine

HRID 639811ノート

反応式

HRID 639811 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[N:13]=[N:12][C:11]([CH:14]([OH:16])[CH3:15])=[N:10]1.[H-].[Na+].[CH:19]1([N:22]2[C:26](S(C)(=O)=O)=[N:25][N:24]=[C:23]2[C:31]2[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=2)[CH2:21][CH2:20]1>>[CH:19]1([N:22]2[C:26]([O:16][CH:14]([C:11]3[N:12]=[N:13][N:9]([C:3]4[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=4[F:1])[N:10]=3)[CH3:15])=[N:25][N:24]=[C:23]2[C:31]2[CH:32]=[CH:33][N:34]=[CH:35][CH:36]=2)[CH2:21][CH2:20]1

参加物

4

反応物 3

HCID 24758Sodium hydrideHCID 578379334-(4-Cyclopropyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)-pyridineHCID 684296401-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethanol

生成物 1

HCID 684311214-(4-Cyclopropyl-5-{1-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4H-[1,2,4]triazol-3-yl)-pyridine

実験手順

The title compound is prepared from 1-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethanol (1 mmol), sodium hydride (1.5 mmol) and 4-(4-cyclopropyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)-pyridine (1.25 mmol).

出典と根拠

ORDレコード
ord-5bd6eae31435464f89f054d85dd61a27
出典データセット
uspto-grants-2010_04
特許番号
US07691892B2

反応ノート

読み込み中…