Nitric Acid → 4-Fluoro-3-nitrobenzaldehyde

HRID 64051

反応式

HRID 64051 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=1>S(=O)(=O)(O)O>[F:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][C:7]=1[N+:1]([O-:4])=[O:2]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 680234-Fluorobenzaldehyde

生成物 1

HCID 5981294-Fluoro-3-nitrobenzaldehyde収率 77%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
5 °C

実験手順

Nitration mixture (sulfuric acid 40 ml+nitric acid 5.5 ml) was added dropwise to 4-fluorobenzaldehyde (10 g, 80.57 mmol) at 0° C. and the mixture was stirred at 5° C. for 20 min and at RT for 1 h. The mixture was quenched by the addition of crushed ice. The precipitate formed was filtered and was washed repeatedly with water to give white solid. The solid was dried under vacuum to give the product in 77% yield (10.5 g). 1H NMR (300 MHz, CDCl3): δ 10.04 (s, 1H), 8.58 (dd, 1H), 8.22-8.18 (m, 1H), 7.5 (t, 1H).

後処理

  1. customThe mixture was quenched by the addition of crushed ice
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. washwas washed repeatedly with water
  5. customto give white solid
  6. customThe solid was dried under vacuum
  7. customto give the product in 77% yield (10.5 g)

出典と根拠

ORDレコード
ord-102b47a80918421a8aefdc9de808d131
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

関連ノート

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