Nitric Acid → 4-Fluoro-3-nitrobenzaldehyde
反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=1>S(=O)(=O)(O)O>[F:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][C:7]=1[N+:1]([O-:4])=[O:2]参加物
4
反応条件
- 温度
- 5 °C
実験手順
Nitration mixture (sulfuric acid 40 ml+nitric acid 5.5 ml) was added dropwise to 4-fluorobenzaldehyde (10 g, 80.57 mmol) at 0° C. and the mixture was stirred at 5° C. for 20 min and at RT for 1 h. The mixture was quenched by the addition of crushed ice. The precipitate formed was filtered and was washed repeatedly with water to give white solid. The solid was dried under vacuum to give the product in 77% yield (10.5 g). 1H NMR (300 MHz, CDCl3): δ 10.04 (s, 1H), 8.58 (dd, 1H), 8.22-8.18 (m, 1H), 7.5 (t, 1H).
後処理
- customThe mixture was quenched by the addition of crushed ice
- customThe precipitate formed
- filtrationwas filtered
- washwas washed repeatedly with water
- customto give white solid
- customThe solid was dried under vacuum
- customto give the product in 77% yield (10.5 g)
出典と根拠
- ORDレコード
- ord-102b47a80918421a8aefdc9de808d131
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447091B2
反応ノート
読み込み中…