Potassium Carbonate → 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole

HRID 64053

反応式

HRID 64053 の反応式
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH:6]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 81503Bromomethylcyclopropane

生成物 1

HCID 510722584-Bromo-1-(cyclopropylmethyl)-1H-pyrazole収率 109.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-bromo-1H-pyrazole (0.1 g, 0.68 mmol) in DMF (20 ml) were added K2CO3 (0.19 g, 1.36 mmol, 2 eq.) and (bromomethyl)cyclopropane (92 mg, 0.68 mmol, 1 eq.). The mixture was stirred at RT for 4 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude product (0.15 g).

後処理

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(c)
  3. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-a167ce228617490a96ee8259ff7c99af
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

関連ノート

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