Hydrogen Bromide → (4aR,7aR)-Octahydro-1H-pyrrolo(3,4-b)pyridine

HRID 640676ノート

反応式

HRID 640676 の反応式
C1(C)C=CC(S([N:10]2[CH2:18][C@@H:17]3[C@@H:12]([NH:13][CH2:14][CH2:15][CH2:16]3)[CH2:11]2)(=O)=O)=CC=1.Br.C(O)(=O)CC.C1(O)C=CC=CC=1>>[C@H:12]12[CH2:11][NH:10][CH2:18][C@H:17]1[CH2:16][CH2:15][CH2:14][NH:13]2

参加物

5

反応物 4

HCID 260Hydrogen BromideHCID 996PhenolHCID 1032Propionic AcidHCID 44227364(R,R)-6-(toluene-4-sulfonyl)-octahydro-pyrrolo[3,4-b]pyridine

生成物 1

HCID 1515156(4aR,7aR)-Octahydro-1H-pyrrolo(3,4-b)pyridine収率 84.4%

実験手順

The title compound (9.12 g) is prepared from mixture system of (R,R)-6-(toluene-4-sulfonyl)-octahydro-pyrrolo[3,4-b]pyridine (24.0 g), hydrobromic acid (48%, 156 ml), propionic acid (72 ml) and phenol (14.6 g) following the same procedure described in example 9. After conventional work up and distillation 3.4 g of oil is obtained (yield: 78.0%).

後処理

  1. distillationAfter conventional work up and distillation 3.4 g of oil
  2. customis obtained (yield: 78.0%)

出典と根拠

ORDレコード
ord-88b39cc0ec8649c9be66aa8c615bfd7f
出典データセット
uspto-grants-2010_04
特許番号
US07692015B2

反応ノート

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