Iodine → HCID 59256517、化合物
反応式
[Cl:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([CH:6]=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C([O-])(=O)C.[K+].[I:18]I>CO.O>[Cl:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([CH:6]=[N:7][CH:8]=[N:9]2)=[C:4]([I:18])[CH:3]=1参加物
6
実験手順
To a solution of 7-chloro-8-hydroxy-quinazoline (A69) (0.1 mol) and potassium acetate (0.15 mol) in MeOH and H2O (19:1, 250 mL) was added, over 30 min, a solution of iodine (0.095 mol) in MeOH and H2O (19:1, 350 mL). The mixture was then heated under reflux for 15 min, cooled and H2O (400 mL) was added. The precipitate was isolated by filtration, washed with saturated sodium thiosulfate and H2O, and dried. This provided 7-chloro-8-hydroxy-5-iodo-quinazoline (A70) as a solid.
後処理
- temperatureThe mixture was then heated
- temperatureunder reflux for 15 min
- temperaturecooled
- customThe precipitate was isolated by filtration
- washwashed with saturated sodium thiosulfate and H2O
- customdried
出典と根拠
- ORDレコード
- ord-2e544adad0164fb29db51e6853339a81
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07692011B2
反応ノート
読み込み中…