Sodium Hydroxide → Y-39983
反応式
[ClH:1].Cl.[NH:3]1[C:7]2=[N:8][CH:9]=[CH:10][C:11]([NH:12][C:13](=[O:23])[C:14]3[CH:19]=[CH:18][C:17]([C@H:20]([NH2:22])[CH3:21])=[CH:16][CH:15]=3)=[C:6]2[CH:5]=[CH:4]1.[OH-].[Na+]>O>[ClH:1].[NH:3]1[C:7]2=[N:8][CH:9]=[CH:10][C:11]([NH:12][C:13](=[O:23])[C:14]3[CH:19]=[CH:18][C:17]([C@H:20]([NH2:22])[CH3:21])=[CH:16][CH:15]=3)=[C:6]2[CH:5]=[CH:4]1参加物
4
反応条件
- 温度
- 60 °C
実験手順
(R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide dihydrochloride 3/2 hydrate (8.5 g) obtained in Reference Example 1 was dissolved in water (50 mL) and 1N—NaOH aqueous solution was added dropwise while stirring under ice-cooling. The precipitated crystals were collected by filtration and dried (warm air: 60° C., 10 hrs) to give a free base form (6.2 g).