Ammonium Chloride → N-(5-aminobiphenyl-3-yl)acetamide

HRID 64131ノート

反応式

HRID 64131 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([NH:16][C:17](=[O:19])[CH3:18])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:9]=1)([O-])=O.[Cl-].[NH4+]>C1COCC1.O.[Zn]>[NH2:1][C:4]1[CH:5]=[C:6]([NH:16][C:17](=[O:19])[CH3:18])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:9]=1

参加物

6

反応物 2

HCID 25517Ammonium ChlorideHCID 89500237N-(5-nitrobiphenyl-3-yl)acetamide

生成物 1

HCID 308689N-(5-aminobiphenyl-3-yl)acetamide収率 94%

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
45 °C

実験手順

To a solution of N-(5-nitrobiphenyl-3-yl)acetamide (1.2 g, 4.68 mmol) in THF (10 ml) were added a solution of ammonium chloride (2 g, 37.4 mmol, 8 eq.) in water (2 ml) and zinc (2.36 g, 37.4 mmol, 8 eq.). The mixture was stirred at 45° C. for 2 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off to afford the product in 94% yield (1 g).

後処理

  1. filtrationfiltered
  2. additionThe filtrate was diluted with water
  3. extractionextracted as in Example 1(d)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 94% yield (1 g)

出典と根拠

ORDレコード
ord-acba007b2aea44e299dfd5be3b4dfb87
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

反応ノート

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