Potassium Nitrate → 4,6-Dichloro-7-nitro-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one
反応式
[Cl:1][C:2]1[C:7]2[NH:8][C:9](=[O:11])[NH:10][C:6]=2[CH:5]=[C:4]([Cl:12])[N:3]=1.[N+:13]([O-])([O-:15])=[O:14].[K+]>OS(O)(=O)=O>[Cl:1][C:2]1[C:7]2[NH:8][C:9](=[O:11])[NH:10][C:6]=2[C:5]([N+:13]([O-:15])=[O:14])=[C:4]([Cl:12])[N:3]=1参加物
4
反応条件
- 温度
- 125 °C
実験手順
To a solution of 4,6-dichloro-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (0.6 g, 2.94 mmol) from Step C in conc. H2SO4 (15 mL) was added KNO3 (2.97 g, 29.4 mmol) and the reaction mixture was heated at 125° C. for 2 h. After cooling, the reaction was mixed with ice and the solid precipitate was isolated by filtration and washed with cold H2O to give the title compound. MS: m/z=290 (M+1+CH3CN).
後処理
- temperatureAfter cooling
- additionthe reaction was mixed with ice
- customthe solid precipitate was isolated by filtration
- washwashed with cold H2O
出典と根拠
- ORDレコード
- ord-32d1426d967b435e992ae945861774b4
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696192B2
反応ノート
読み込み中…