Sodium Hydroxide → Disodium 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

HRID 641528ノート

反応式

HRID 641528 の反応式
[OH-].[Na+:2].[CH:3]1([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][C:16]([O:18][C:19]4[N:24]=[C:23]([C:25]([O:27]C)=[O:26])[C:22]([C:29]([O:31]C)=[O:30])=[CH:21][CH:20]=4)=[CH:17][C:10]=3[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4]1>O.C(O)C>[CH:3]1([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][C:16]([O:18][C:19]4[N:24]=[C:23]([C:25]([O-:27])=[O:26])[C:22]([C:29]([O-:31])=[O:30])=[CH:21][CH:20]=4)=[CH:17][C:10]=3[CH2:9][CH2:8]2)[CH2:4][CH2:5][CH2:6]1.[Na+:2].[Na+:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 10070139Dimethyl 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

生成物 1

HCID 10365123Disodium 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Sodium hydroxide (0.66 g) in water (3 ml) was added to a solution of dimethyl 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate (E231) (1.69 g, 4.12 mmol) in ethanol (20 ml) at room temperature. The mixture was vigorously stirred at room temperature for 4 h and the resulting precipitate filtered off to give the title compound as a colourless solid (E232); MS (ES+) m/e 383 [M+H]+.

後処理

  1. filtrationthe resulting precipitate filtered off

出典と根拠

ORDレコード
ord-32f692ce9bda400f873133c2646476a7
出典データセット
uspto-grants-2010_04
特許番号
US07696193B2

反応ノート

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