N-bromobutanimide → HCID 178433332、化合物
反応式
[NH2:1][C:2]1[N:3]=[C:4]([CH3:23])[C:5]2[CH:11]=[CH:10][C:9](=[O:12])[N:8]([C@H:13]3[CH2:18][CH2:17][C@@H:16]([O:19][CH2:20][CH2:21][OH:22])[CH2:15][CH2:14]3)[C:6]=2[N:7]=1.[Br:24]N1C(=O)CCC1=O>CN(C)C=O>[NH2:1][C:2]1[N:3]=[C:4]([CH3:23])[C:5]2[CH:11]=[C:10]([Br:24])[C:9](=[O:12])[N:8]([C@H:13]3[CH2:14][CH2:15][C@@H:16]([O:19][CH2:20][CH2:21][OH:22])[CH2:17][CH2:18]3)[C:6]=2[N:7]=1参加物
4
実験手順
To a solution of 2-amino-8-(cis-4-(2-hydroxyethoxy)cyclohexyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one (411 mg, 1.29 mmol) in dimethylformamide (10 mL) was added N-bromosuccinimide (253 mg, 1.42 mmol). After stirring for 1 hour at room temperature the solution was concentrated. The residue was dissolved in chloroform (250 mL) and washed with 1 N sodium carbonate (2×25 mL) and brine (25 mL). The organic layer was dried (Na2SO4), filtered and concentrated. The crude product was purified by flash chromatography eluting with 1:1 ethyl acetate:chloroform/7N ammonia in methanol (0-4%) to afford the title compound (382 mg, 75%).