Phosphorus oxychloride → 7-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate

HRID 641735ノート

反応式

HRID 641735 の反応式
[C:1]([O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=O)[NH:10][CH:11]=[N:12]2)=[C:7]([O:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:6]=1)(=[O:3])[CH3:2].C(N(C(C)C)CC)(C)C.P(Cl)(Cl)([Cl:34])=O>ClCCCl>[C:1]([O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:34])=[N:10][CH:11]=[N:12]2)=[C:7]([O:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 1355106777-(Acetyloxy)-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4(3H)-quinazolinone

生成物 1

HCID 221407987-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
80 °C

実験手順

A mixture of 7-acetoxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one (3.04 g), diisopropylethylamine (4.34 ml), phosphoryl chloride (1.02 ml) and 1,2-dichloroethane (60 ml) was stirred and heated to 80° C. for 2 hours. The mixture was evaporated to give 7-acetoxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline which was used without further purification.

後処理

  1. customThe mixture was evaporated

出典と根拠

ORDレコード
ord-e0e98ad953b3488dbae7ae325bc887be
出典データセット
uspto-grants-2010_04
特許番号
US07696214B2

反応ノート

読み込み中…