Methyl iodide → 5-Bromo-2-methyl-8-nitroisoquinolin-2-ium iodide
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[I:15][CH3:16]>CN(C=O)C>[I-:15].[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N+:6]([CH3:16])=[CH:7]2参加物
4
反応条件
- 温度
- 40 °C
実験手順
Into a 500 mL round bottom flask, was placed a solution of 5-bromo-8-nitroisoquinoline (25.59 g, 101.11 mmol) in DMF (200 mL). To the mixture was added iodomethane (71.8 g, 505.99 mmol). The resulting solution was allowed to react, with stirring, overnight while the temperature was maintained at 40° C. A filtration was performed. The filter cake was washed 2 times with 250 mL of ether. This resulted in 33.33 g (83%) of 5-bromo-8-nitro-N-methylisoquinolinium iodide as a red solid.
後処理
- customInto a 500 mL round bottom flask, was placed
- customto react
- filtrationA filtration
- washThe filter cake was washed 2 times with 250 mL of ether
- customThis resulted in 33.33 g (83%) of 5-bromo-8-nitro-N-methylisoquinolinium iodide as a red solid
出典と根拠
- ORDレコード
- ord-39c719e9a6404df1996d34584b241dea
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696229B2
反応ノート
読み込み中…