HCID 57421405、化合物 → 3-(Oxan-2-yloxy)pyrrolidine
反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH:8]1[CH2:12][CH2:11][N:10](C(OCC2C=CC=CC=2)=O)[CH2:9]1>CO.[Pd]>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH:8]1[CH2:12][CH2:11][NH:10][CH2:9]1参加物
4
実験手順
Into a 250 mL round bottom flask was placed a solution of benzyl 3-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine-1-carboxylate (15 g, 44.26 mmol) and Pd/C (2.3 g) in CH3OH (absolute) (100 mL). Hydrogen gas was bubbled. The resulting solution was allowed to react, with stirring, for 2 hours while the temperature was maintained at room temperature. A filtration was performed. The filtrate was concentrated by evaporation under vacuum using a rotary evaporator. This resulted in 5.6 g (67%) of 3-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine as a yellow liquid.
後処理
- customInto a 250 mL round bottom flask was placed
- customHydrogen gas was bubbled
- customto react
- filtrationA filtration
- concentrationThe filtrate was concentrated by evaporation under vacuum
- customa rotary evaporator
- customThis resulted in 5.6 g (67%) of 3-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine as a yellow liquid
出典と根拠
- ORDレコード
- ord-dcf3638e51724618ada8135a6404cd46
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696229B2
反応ノート
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