関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1H-1,2,3-Triazole | HCID 67516 | — |
| 反応物 | 3-Bromo-5-methylpyridine-2-carbonitrile | HCID 22591218 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Methyl-3-(2H-1,2,3-triazol-2-yl)picolinonitrile | HCID 68281582 | 49.1% |
反応手順
To 3-bromo-5-methylpicolinonitrile (2.2 g, 11 mmol) in DMF (28 mL) was added K2CO3 (1.7 g, 12 mmol) and 2H-1,2,3-triazole (650 μL, 11 mmol). The mixture was heated to 100° C. for 36 h, cooled to rt and extracted with EtOAc. The combined organics were dried (Na2SO4) and concentrated. Purification via silica gel chromatography (10-100% EtOAc in hexanes) gave the title compound (1 g, 48%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447117B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-9f9d198fef8b4b5d9241029a89f23e2a |
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| 出典メモ | uspto-grants-2016_09 |
|---|
