反应详情

温度

100 °C

To 3-bromo-5-methylpicolinonitrile (2.2 g, 11 mmol) in DMF (28 mL) was added K2CO3 (1.7 g, 12 mmol) and 2H-1,2,3-triazole (650 μL, 11 mmol). The mixture was heated to 100° C. for 36 h, cooled to rt and extracted with EtOAc. The combined organics were dried (Na2SO4) and concentrated. Purification via silica gel chromatography (10-100% EtOAc in hexanes) gave the title compound (1 g, 48%).

1. temperaturecooled to rt
2. extractionextracted with EtOAc
3. dry with materialThe combined organics were dried (Na2SO4)
4. concentrationconcentrated
5. customPurification via silica gel chromatography (10-100% EtOAc in hexanes)