Benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate → 4-(2-Hydrazino-2-oxoethoxy)benzoic acid
反応式
[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([O:12]CC2C=CC=CC=2)=[O:11])=[CH:8][CH:7]=1)[NH2:2]>CC(O)=O.[Pd]>[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)[NH2:2]参加物
4
実験手順
In an Parr autoclave, a solution of benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate (400 mg, 1.3 mmol) and a catalytic amount Pd/C in AcOH (25 mL) was stirred under hydrogen pressure (5 Bars) at rt for 45 min. After filtration over celite, the filtrate was evaporated off. The residue was taken up in MeOH and a beige solid precipitated out. Filtration and drying under vacuo at 50° C. overnight gave the title compound as a beige solid (118 mg) in a 42% yield.
後処理
- filtrationAfter filtration over celite
- customthe filtrate was evaporated off
- customa beige solid precipitated out
- filtrationFiltration
- customdrying under vacuo at 50° C. overnight
出典と根拠
- ORDレコード
- ord-7eff46c438b449c48828ec83b8c1e2f2
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696231B2
反応ノート
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