1-Benzyl-4-(hydroxymethyl)piperidin-4-ol → 4-(Hydroxymethyl)piperidin-4-ol
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][OH:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[OH:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1参加物
5
実験手順
A suspension of 26.0 g (117 mmol) 1-benzyl-4-hydroxymethyl-piperidin-4-ol and 5.0 g 10% Pd/C in 500 mL MeOH was hydrogenated at 50° C. and 3 bar hydrogen pressure until the theoretical hydrogen uptake had occurred (4 h). The catalyst was filtered off and washed with MeOH. After the solvent had been eliminated the residue was reacted further without purification.
後処理
- customwas hydrogenated at 50° C.
- custom(4 h)
- filtrationThe catalyst was filtered off
- washwashed with MeOH
- customwas reacted further without purification
出典と根拠
- ORDレコード
- ord-296e78c1935344c180208533e9baa118
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696195B2
反応ノート
読み込み中…