反応式
[F:1][C:2]([F:13])([F:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[F:13][C:2]([F:1])([F:12])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]([F:11])=[CH:9][CH:10]=1)[OH:4]参加物
4
反応条件
- 温度
- 25 °C
実験手順
To a stirred solution of 2,2,2,4′-tetrafluoroacetophenone (10 g, 52.1 mmol) in methanol (50 mL) was added NaBH4 (0.98 g, 26.5 mmol) at 0° C. After stirring at 25° C. for 2 h, the reaction mixture was quenched by adding 1N HCl (100 mL) and then extracted with ethyl ether. The ether extract was washed with brine, dried with MgSO4, and concentrated to give 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol (11.32 g) which was used in next step without further purification.
後処理
- customthe reaction mixture was quenched
- additionby adding 1N HCl (100 mL)
- extractionextracted with ethyl ether
- extractionThe ether extract
- washwas washed with brine
- dry with materialdried with MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c19864ec4263411ab3e3e915a509ca58
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696250B2
関連ノート
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