Water → 4-Azidomethyl 1-(4-iodophenyl)imidazole
反応式
Cl[CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)[CH:7]=1.[N-:15]=[N+:16]=[N-:17].[Na+].O.CCOC(C)=O>CN(C=O)C>[N:15]([CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)[CH:7]=1)=[N+:16]=[N-:17]参加物
6
実験手順
The compound 4-(chloromethyl)-1-(4-iodophenyl)-1H-imidazole 9.5 (0.780 g, 2.45 mmol) was dissolved in DMF (10 mL). To the solution, NaN3 (0.520 g, 8.00 mmol) was added. After being stirred at room temperature overnight, water and EtOAc were added. The organic layer was separated, dried over Na2SO4, concentrated in vacuo to give 4-(azidomethyl)-1-(4-iodophenyl)-1H-imidazole 9.6 as a solid (0.725 g). MS 326.0 (M+H).
後処理
- customThe organic layer was separated
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-0c6c826637bc45d0ac56a9339b91371a
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696352B2
反応ノート
読み込み中…