3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine

HRID 643036

反応式

HRID 643036 の反応式
[N:1]([CH2:4][C:5]1[CH:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=2)[N:6]=1)=[N+]=[N-]>CO.[Ni]>[I:16][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH:8]=[CH:9][C:5]([CH2:4][NH2:1])=[N:6]2)=[CH:15][CH:14]=1

参加物

4

反応物 1

HCID 866140093-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole

生成物 1

HCID 65805535(1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine収率 84.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (100 mg, 0.31 mmol) and Ra—Ni (50% aq. slurry, 150 mg) in MeOH (8 mL) was hydrogenated under balloon H2 for 3 hrs. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine (78 mg).

後処理

  1. filtrationIt was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-a56343b3dbb74dd782d128e53a759453
出典データセット
uspto-grants-2010_04
特許番号
US07696352B2

関連ノート

読み込み中…