Hydrochloric Acid → Phthalylglycine aldehyde

HRID 643074

反応式

HRID 643074 の反応式
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[O:18]1CC[CH2:20][CH2:19]1>>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:20][CH:19]=[O:18]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 66899166Phthalimide diethylacetal

生成物 1

HCID 76201Phthalylglycine aldehyde

反応条件

温度
75 °C

実験手順

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to room temperature, and ethyl acetate was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

後処理

  1. temperatureto cool to room temperature
  2. customethyl acetate was separated
  3. dry with materialdried over magnesium sulfate (MgSO4)
  4. filtrationThe solution was filtered
  5. customevaporated

出典と根拠

ORDレコード
ord-d36663426f704177947eda52ba39cdbd
出典データセット
uspto-grants-2010_04
特許番号
US07696226B2

関連ノート

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