HCID 136928067、化合物 → HCID 136928110、化合物

HRID 64308ノート

反応式

HRID 64308 の反応式
C([N:8]1[CH2:13][CH2:12][C:11]2([N:17]3[N:18]=[C:19]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.CC(O)=O.[OH-].[OH-].[Pd+2]>[O:30]([C:27]1[CH:26]=[CH:25][C:24]([C:19]2[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14][C:11]4([CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[N:17]3[N:18]=2)=[CH:29][CH:28]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

参加物

5

反応物 1

HCID 136928067HCID 136928067、化合物

生成物 1

HCID 136928110HCID 136928110、化合物収率 51.4%

試薬・触媒・溶媒 3

HCID 176Acetic Acid触媒HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of 1′-benzyl-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide (50 mg, 0.10 mmol), 10% w/w Pd(OH)2/C (5 mg) in MeOH (10 mL) and HOAc (1 drop) was stirred for 16 hr under H2. The mixture was filtrated and the filtrate was concentrated to give the crude product (20 mg 51.4%) as a yellow solid. MS (ESI, m/e) [M+1]+ 390.0.

後処理

  1. filtrationThe mixture was filtrated
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-2eeb7802e5a74bebb486d86771d06c3a
出典データセット
uspto-grants-2016_09
特許番号
US09447106B2

反応ノート

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