Sodium borohydride → (2-Fluoro-4-nitrophenyl)methanol

HRID 64336

反応式

HRID 64336 の反応式
[F:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 45629192-Fluoro-4-nitrobenzaldehyde

生成物 1

HCID 17981733(2-Fluoro-4-nitrophenyl)methanol収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-fluoro-4-nitrobenzaldehyde (1.0 g, 5.92 mmol) in CH3OH (10 mL) was added NaBH4 (814 mg, 22 mmol). After stirring at RT for 15 min, the mixture was concentrated. The residue was partitioned between 100 mL of EA and 100 mL of brine. The combined organic layers were washed with brine (100 mL×2), dried over Na2SO4, and concentrated to afford 1.0 g of (2-fluoro-4-nitrophenyl) methanol (99%) as a red solid. MS (ESI) m/e [M+1]+ 172.0.

後処理

  1. concentrationthe mixture was concentrated
  2. customThe residue was partitioned between 100 mL of EA and 100 mL of brine
  3. washThe combined organic layers were washed with brine (100 mL×2)
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-cf1bd06299bd4455957dcef8c4381f7e
出典データセット
uspto-grants-2016_09
特許番号
US09447106B2

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