Methyl iodide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester
反応式
I[CH3:2].[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([SH:15])[N:5]=1>CN(C)C=O>[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:2])[N:5]=1参加物
4
実験手順
Iodomethane (2.6 g, 18 mmol) was added to the hot solution (˜50° C.) of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (3.0 g, 15 mmol) in N,N-dimethylformamide (150 mL) and stirred at room temperature for 20 min. Solvent was removed in vacuo and the solid residue was washed by water. After dried in vacuo, desired product was obtained as a white solid (3.1 g, 97%).
後処理
- customSolvent was removed in vacuo
- washthe solid residue was washed by water
- customAfter dried in vacuo
出典と根拠
- ORDレコード
- ord-53fa3e6a94484237aa6b32775fcfe148
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07700622B2
反応ノート
読み込み中…