5,6,7,8-Tetrahydro-2-naphthol → 1-Bromo-5,6,7,8-tetrahydro-2-naphthalenol
反応式
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[OH:11].C1C(=O)N([Br:19])C(=O)C1>CN(C=O)C>[Br:19][C:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[OH:11]参加物
4
実験手順
To a solution of 5,6,7,8-tetrahydro-2-naphthol (2.50 g, 16.9 mmol) in DMF (5 mL), is added dropswise NBS (3.0 g, 16.9 mmol). The solution is stirred at room temperature for 18 h. The mixture is washed with water, extracted with CH2Cl2, dried over MgSO4 and concentrated. The crude material is purified via Biotage, eluting with 5-40% EtOAc/hexanes to afford 1-bromo-5,6,7,8-tetrahydronaphthalen-2-ol.
後処理
- washThe mixture is washed with water
- extractionextracted with CH2Cl2
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe crude material is purified via Biotage
- washeluting with 5-40% EtOAc/hexanes
出典と根拠
- ORDレコード
- ord-1ebb5123b4644fd49450b46042036ffb
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07700633B2
反応ノート
読み込み中…