Water → Methyl 2-chloro-3-cyclopropyl-3-oxopropanoate
反応式
[CH:1]1([C:4](=[O:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:3][CH2:2]1.S(Cl)([Cl:14])(=O)=O.O.C(Cl)(Cl)Cl>ClCCl>[Cl:14][CH:5]([C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:10])[C:6]([O:8][CH3:9])=[O:7]参加物
6
実験手順
To a solution of 2 g of methyl 3-cyclopropyl-3-oxopropanoate in 20 ml of dichloromethane was added dropwise 1.24 ml of sulfuryl chloride under ice-cooling, followed by stirring at room temperature for 5 hours. To the reaction mixture was added water under ice-cooling, and chloroform was further added thereto to carry out a layer separation operation. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 2.48 g of methyl 2-chloro-3-cyclopropyl-3-oxopropanoate.
後処理
- temperaturecooling
- temperaturecooling
- customa layer separation operation
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-8efff6a422124e31b24a243c767fe4c8
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447090B2
反応ノート
読み込み中…