2-[4-(Morpholin-4-yl)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide → N-(5-Chloropyridin-2-yl)-2-[4-(morpholin-4-yl)-2-(piperidin-4-yloxy)-benzoylamino]benzamide

HRID 644171

反応式

HRID 644171 の反応式
[N:1]1([C:7]2[CH:31]=[CH:30][C:10]([C:11]([NH:13][C:14]3[CH:29]=[CH:28][CH:27]=[CH:26][C:15]=3[C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][N:20]=3)=[O:17])=[O:12])=[C:9]([O:32][CH:33]3[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]3)[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>C(O)(C(F)(F)F)=O>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:26]=[CH:27][CH:28]=[CH:29][C:14]=2[NH:13][C:11](=[O:12])[C:10]2[CH:30]=[CH:31][C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[CH:8][C:9]=2[O:32][CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:20][CH:21]=1

参加物

3

反応物 1

HCID 685307202-[4-(Morpholin-4-yl)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

生成物 1

HCID 57860933N-(5-Chloropyridin-2-yl)-2-[4-(morpholin-4-yl)-2-(piperidin-4-yloxy)-benzoylamino]benzamide収率 100%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The 2-[4-(morpholin-4-yl)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide (164 mg, 0.26 mmol) was dissolved in TFA (3 mL). After 5 minutes, the reaction was concentrated in vacuo. The residue was diluted with methylene chloride (100 mL) and washed with saturated aqueous sodium carbonate. The organic layer was dried over sodium sulfate, filtered, and concentrated to give the desired product (138 mg, 0.26 mmol, 100%).

後処理

  1. concentrationthe reaction was concentrated in vacuo
  2. additionThe residue was diluted with methylene chloride (100 mL)
  3. washwashed with saturated aqueous sodium carbonate
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-28659d2b8566450fbd579d3fca1e141d
出典データセット
uspto-grants-2010_04
特許番号
US07700628B2

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