Methanol → methyl rac-(1R,2R)-1-aminoindane-2-carboxylate hydrochloride
反応式
C(OC([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[C:18]([OH:20])=[O:19])=O)(C)(C)C.S(Cl)([Cl:23])=O.[CH3:25]O>>[ClH:23].[NH2:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[C:18]([O:20][CH3:25])=[O:19]参加物
4
実験手順
To a suspension of 750 mg of rac-(1R,2R)-1-[(tert-butoxycarbonyl)amino]indane-2-carboxylic acid in 15 ml of methanol was added 0.40 ml of thionyl chloride, followed by stirring overnight. The solvent was evaporated to about a half amount thereof under reduced pressure, to the obtained residue was added diethyl ether, and the insoluble material was collected by filtration and dried to obtain 512 mg of methyl rac-(1R,2R)-1-aminoindane-2-carboxylate hydrochloride.
後処理
- customThe solvent was evaporated to about a half amount
- additionunder reduced pressure, to the obtained residue was added diethyl ether
- filtrationthe insoluble material was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-460ce756d8c747909d62ad09cb7b4b3b
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447090B2
反応ノート
読み込み中…