4,4-Difluoro-1′-(phenylmethyl)-1,4′-bipiperidine → 4,4-difluoro-1,4'-bipiperidine

HRID 644330ノート

反応式

HRID 644330 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][C:17]([F:21])([F:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.Cl.[Pd]>[F:21][C:17]1([F:20])[CH2:18][CH2:19][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15][CH2:16]1

参加物

6

反応物 2

HCID 685813714,4-Difluoro-1′-(phenylmethyl)-1,4′-bipiperidineHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 534187744,4-difluoro-1,4'-bipiperidine

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 2.8 g (9.5 mmol) 1′-benzyl-4,4-difluoro-[1,4′]bipiperidinyl in 300 mL MeOH was hydrogenated in the presence of 1.2 g Pd/C (10%) at 50° C. and 50 psi hydrogen pressure with the addition of a few drops of 1 M HCl until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down under reduced pressure. The residue was triturated with diisopropylether, suction filtered and dried.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down under reduced pressure
  3. customThe residue was triturated with diisopropylether, suction
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-b9641564546c46fb8ebb21f5e72aff44
出典データセット
uspto-grants-2010_04
特許番号
US07700589B2

反応ノート

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