4-Azetidin-1-yl-1-benzyl-piperidine → 4-(Azetidin-1-YL)piperidine

HRID 644356ノート

反応式

HRID 644356 の反応式
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8](CC3C=CC=CC=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 231533994-Azetidin-1-yl-1-benzyl-piperidineHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 231531094-(Azetidin-1-YL)piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3.2 g (13.9 mmol) 4-azetidin-1-yl-1-benzyl-piperidine dissolved in 50 mL MeOH were hydrogenated in the autoclave in the presence of 0.5 g Pd/C (10%) at 50° C. and 3 bar hydrogen pressure until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the solvent was eliminated under reduced pressure.

後処理

  1. filtrationThe catalyst was filtered off

出典と根拠

ORDレコード
ord-a920274d7d824753a91b7afa7bd1fc4f
出典データセット
uspto-grants-2010_04
特許番号
US07700589B2

反応ノート

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