Trifluoroacetic acid → 4-(3,4-Dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:5]=[CH:6][C:7]=1[CH3:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:19]([O:21][CH2:22][CH3:23])=[O:20])([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[CH3:8]参加物
4
実験手順
A mixture of 11.6 g (29.5 mmol) tert-butyl 4-(3,4-dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoate and 100 mL DCM was combined with 20 mL TFA, the reaction mixture was stirred for 3 h at RT and evaporated down under reduced pressure.