Benzaldehyde → 7-(N-benzylideneamino)-1-phenyl-5-trifluoromethylbenzimidazole

HRID 644504ノート

反応式

HRID 644504 の反応式
[NH2:1][C:2]1[C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[CH:3]=1.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH:21](=[N:1][C:2]1[C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[CH:3]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 6101p-Toluenesulfonic acidHCID 113003637-Amino-1-phenyl-5-trifluoromethylbenzimidazole

生成物 1

HCID 114172137-(N-benzylideneamino)-1-phenyl-5-trifluoromethylbenzimidazole

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 7-amino-1-phenyl-5-trifluoromethylbenzimidazole (0.50 g, 1.81 mmol) in anhydrous toluene (10 ml) was added benzaldehyde, p-toluenesulphonic acid (10 mg) and molecular sieves. The resultant mixture was stirred at reflux for 1.5 hours. The molecular sieves were removed by filtration and the filtrate was concentrated under reduced pressure. The concentrate was partitioned between aqueous sodium carbonate (2M) and ethyl acetate. The organic phase was dried and concentrated, and the concentrate was eluted through silica gel with a mixture of ethyl acetate and ligroin (1:1 v/v). Removal of solvent from the eluate left the desired product as a yellow solid (0.37 g, 56%) m/z, 366.1 (M+H)+.

後処理

  1. temperatureat reflux for 1.5 hours
  2. customThe molecular sieves were removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe concentrate was partitioned between aqueous sodium carbonate (2M) and ethyl acetate
  5. customThe organic phase was dried
  6. concentrationconcentrated
  7. washthe concentrate was eluted through silica gel with a mixture of ethyl acetate and ligroin (1:1 v/v)
  8. customRemoval of solvent from the eluate
  9. waitleft the desired product as a yellow solid (0.37 g, 56%) m/z, 366.1 (M+H)+

出典と根拠

ORDレコード
ord-5c9a39aaa8d74e3c91b89fbc8acc70aa
出典データセット
uspto-grants-2010_04
特許番号
US07700638B2

反応ノート

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