5-Cyano-7-(3-hydroxymethylphenyl)-1-phenylbenzimidazole → 5-Cyano-7-(4-hydroxyphenyl)-1-phenylbenzimidazole
反応式
[C:1]([C:3]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22]C=[C:20]([CH2:24][OH:25])[CH:19]=2)[C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)#[N:2]>C(#N)C>[C:1]([C:3]1[CH:17]=[C:16]([C:18]2[CH:19]=[CH:20][C:24]([OH:25])=[CH:22][CH:23]=2)[C:6]2[N:7]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)#[N:2]参加物
3
実験手順
This was prepared in a similar manner to 5-cyano-7-(3-hydroxymethylphenyl)-1-phenylbenzimidazole, with 90 h reflux before removal of solvent using nitrogen to give an oily residue. The residue was taken up in acetonitrile (3 ml) and the resulting solid filtered off and dried under reduced pressure to give the desired product (490 mg, 77%) m/z, 312.3 (M+H)+.
後処理
- temperaturereflux before removal of solvent
- customto give an oily residue