Dimethylformamide → HCID 59263843、化合物

HRID 644976ノート

反応式

HRID 644976 の反応式
[CH2:1]([O:8][C:9]([N:11]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[CH2:12][CH2:13][C:14](O)=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:27]C1C(Cl)=CC=CC=1CCN.C(Cl)(=O)C(Cl)=O.CN(C=O)C>ClCCl>[Cl:27][C:14](=[O:15])[CH2:13][CH2:12][N:11]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27347582-(2,3-dichlorophenyl)ethanamineHCID 67319255HCID 67319255、化合物

生成物 1

HCID 59263843HCID 59263843、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-((Benzyloxycarbonyl)(3,4-dichlorophenethyl)amino)propanoic acid (0.5 g), prepared according to the procedure of Example 1 step iv), but using 2,3-dichlorophenethylamine instead of phenethylamine, was dissolved in dichloromethane (10 mL) and treated with oxalyl chloride (0.132 mL) and DMF (0.05 mL). The reaction was stirred at room temperature until gas evolution ceased, and the solvent was removed in vacuo to give an oil which was used in step ii) directly.

後処理

  1. customthe solvent was removed in vacuo
  2. customto give an oil which

出典と根拠

ORDレコード
ord-1c63868baad64cccadc8b6c327d2bca9
出典データセット
uspto-grants-2010_04
特許番号
US07700782B2

反応ノート

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