2,3,8a-trimethyl-3,4,4a,5,8,8a-hexahydro-1(2H)-naphthalenone → 2,3,8a-Trimethyloctahydronaphthalen-1(2H)-one

HRID 645334

反応式

HRID 645334 の反応式
[CH3:1][CH:2]1[CH:11]([CH3:12])[CH2:10][CH:9]2[C:4]([CH3:13])([CH2:5][CH:6]=[CH:7][CH2:8]2)[C:3]1=[O:14]>C(OCC)(=O)C.[Pd]>[CH3:1][CH:2]1[CH:11]([CH3:12])[CH2:10][CH:9]2[C:4]([CH3:13])([CH2:5][CH2:6][CH2:7][CH2:8]2)[C:3]1=[O:14]

参加物

4

反応物 1

HCID 574294412,3,8a-trimethyl-3,4,4a,5,8,8a-hexahydro-1(2H)-naphthalenone

生成物 1

HCID 160635322,3,8a-Trimethyloctahydronaphthalen-1(2H)-one収率 98.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

2,3,8a-trimethyl-3,4,4a,5,8,8a-hexahydro-1(2H)-naphthalenone (10 g, 52 mmol) was hydrogenated, at room temperature and atmospheric pressure, in ethyl acetate (100 ml) in presence of 5% Pd—C (1.0 g). The crude product was purified by bulb-to-bulb distillation (78° C./0.035 mbar) to give desired compound (9.88 g, 51 mmol, 98%) as a 3:2 mixture of diastereoisomers.

後処理

  1. customwas hydrogenated, at room temperature
  2. distillationThe crude product was purified by bulb-to-bulb distillation (78° C./0.035 mbar)

出典と根拠

ORDレコード
ord-e1d4afe416e04b76a6d08fcff7dc2034
出典データセット
uspto-grants-2010_04
特許番号
US07704933B2

関連ノート

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