Ammonia → 2-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline

HRID 645352ノート

反応式

HRID 645352 の反応式
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][N:11]([C:16]1[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N+:26]([O-:28])=[O:27])[CH:22]=3)[N:17]=1)[CH2:12]2)=O)(C)(C)C.FC(F)(F)C(O)=O.N>ClCCl>[CH:13]12[NH:8][CH:9]([CH2:15][CH2:14]1)[CH2:10][N:11]([C:16]1[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N+:26]([O-:28])=[O:27])[CH:22]=3)[N:17]=1)[CH2:12]2

参加物

5

反応物 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 686830833-(6-Nitro-quinolin-2-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 119507832-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3-(6-nitro-quinolin-2-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.0 g, 2.6 mmol), trifluoroacetic acid (2.97 g, 26.0 mmol) and dichloromethane (10 ml) was stirred for 15 h. The mixture was made alkaline by adding concentrated ammonia. The mixture was extracted with dichloromethane, dried and evaporated. Yield 0.50 g (90%) Mp 185° C. decomp.

後処理

  1. extractionThe mixture was extracted with dichloromethane
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-5da7f429d1c04681b8419faefc4a3a8b
出典データセット
uspto-grants-2010_04
特許番号
US07704991B2

反応ノート

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