Hydrazine hydrate (1:1) → 2-Phenyl-3-pyrrolidin-1-yl propylamine
反応式
[C:1]1([CH:7]([CH2:20][N:21]2CCCC2)[CH2:8][N:9]2[C:17](=O)[C:16]3[C:11](=CC=CC=3)[C:10]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[C:1]1([CH:7]([CH2:8][N:9]2[CH2:17][CH2:16][CH2:11][CH2:10]2)[CH2:20][NH2:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
A solution of 2-(2-phenyl-3-pyrrolidin-1-yl propyl)isoindole-1,3-dione (3 mmol) and hydrazine monohydrate (6 mmol) in ethanol (10 mL) is refluxed for 3.5 h. The reaction mixture is cooled and filtered through celite. The filtrate is concentrated in vacuo to give the title compound, which is directly used for the next reaction without further purification.
後処理
- temperatureThe reaction mixture is cooled
- filtrationfiltered through celite
- concentrationThe filtrate is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-dafb20952a7f490f84f56ba067909a95
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07704996B2
反応ノート
読み込み中…