Tetrahydrofuran → 2,4-Dichloro-5-pyrimidinecarboxylic acid

HRID 645509

反応式

HRID 645509 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9](Cl)=[O:10])=[CH:4][N:3]=1.C1C[O:15]CC1>O>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([OH:10])=[O:15])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 8028TetrahydrofuranHCID 137841122,4-Dichloropyrimidine-5-carbonyl chloride

生成物 1

HCID 219418962,4-Dichloro-5-pyrimidinecarboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a solution of the 2,4-dichloropyrimidine-5-carbonyl chloride (24 mmol) in THF (24 mL) is added H2O (0.64 mL) at room temperature. The reaction mixture is stirred at room temperature for 0.83 h and then diluted with H2O. The mixture is extracted with AcOEt. The organic extracts are washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo to give the crude titled compound; 1H NMR (CDCl3) δ 6.80 (brs, 1H), 9.18 (s, 1H).

後処理

  1. extractionThe mixture is extracted with AcOEt
  2. washThe organic extracts are washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-a6d60d2669694752a24f9d7362b9c7a5
出典データセット
uspto-grants-2010_04
特許番号
US07704996B2

関連ノート

読み込み中…